BDBM50207898 4'-(2,4-dioxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-biphenyl-3-carbonitrile::CHEMBL230626

SMILES O=C1NC(=O)C2(CCN(Cc3ccc(cc3)-c3cccc(c3)C#N)CC2)N1c1ccccc1

InChI Key InChIKey=CPHIGNAWKKTAEQ-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50207898   

TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50207898(4'-(2,4-dioxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-...)
Affinity DataKi:  45nMAssay Description:Displacement of [125I-Tyr13] from human MCH-R1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50207898(4'-(2,4-dioxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed