BDBM50211424 4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide::CHEMBL248176

SMILES CCNC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12

InChI Key InChIKey=ARMFMDYRYOKSOW-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50211424   

TargetMitogen-activated protein kinase 10(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  57nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 9(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetTranscription factor Jun(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  704nMAssay Description:Inhibition of cJun translocation in IL1beta-stimulated A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetCyclin-dependent kinase 2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211424(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of CDK2 by IMAP technologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed