BDBM50224397 9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::CHEMBL428909::cid_1208332

SMILES COc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O

InChI Key InChIKey=COQPVKMATNFNLG-UHFFFAOYSA-N

Data  2 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50224397   

TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataKi:  7.90nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor coactivator 3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  1.10E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNuclear receptor coactivator 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  1.32E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNuclear receptor coactivator 3(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  8.19E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  9.5nMAssay Description:Antagonist activity at human mGluR1a expressed in CHO cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  9.5nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at human mGluR5b expressed in HEK293 cells assessed by measuring intracellular calcium by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50: >3.00E+3nMAssay Description:Antagonist activity at human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50: >3.00E+3nMAssay Description:Antagonist activity at human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor coactivator 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  1.72E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTegument protein VP16(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  1.42E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50224397(9-dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',...)
Affinity DataIC50:  9.5nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed