BDBM50235830 CHEMBL2006765

SMILES CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1

InChI Key InChIKey=UJBJWYNPUOLFIZ-UHFFFAOYSA-N

Data  65 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 50235830   

TargetTyrosine-protein kinase SYK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 8nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 46nMAssay Description:Inhibition of PAK4 kinase domain (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 57nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 82nMAssay Description:Inhibition of JNK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 83nMAssay Description:Inhibition of RSK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 115nMAssay Description:Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 126nMAssay Description:Inhibition of TrkB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 132nMAssay Description:Inhibition of RET (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 136nMAssay Description:Inhibition of FAK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 139nMAssay Description:Inhibition of MEK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetHepatocyte growth factor-like protein(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 177nMAssay Description:Inhibition of MST1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 211nMAssay Description:Inhibition of CLK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 248nMAssay Description:Inhibition of ROCK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 266nMAssay Description:Inhibition of ALK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 360nMAssay Description:Inhibition of LTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 391nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 413nMAssay Description:Inhibition of ROCK1(unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 433nMAssay Description:Inhibition of JNK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 472nMAssay Description:Inhibition of AURKA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 496nMAssay Description:Inhibition of JAK3 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 502nMAssay Description:Inhibition of INSR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TAO2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 529nMAssay Description:Inhibition of TAOK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 558nMAssay Description:Inhibition of TNK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 606nMAssay Description:Inhibition of SGK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 872nMAssay Description:Inhibition of CK1alpha1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 886nMAssay Description:Inhibition of KDR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 892nMAssay Description:Inhibition of MAP4K4 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 991nMAssay Description:Inhibition of TTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of TYRO3 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of Fyn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of TBK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ABL (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of IGF1R (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of Prkcn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of AURKB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of DYRK1B (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDeath-associated protein kinase 3(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ZIPK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of TrkC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IKKE (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 2.33E+3nMAssay Description:Inhibition of Lck (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of human CAMK1D (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of CDK7 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibition of TRKA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetWee1-like protein kinase(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of Wee1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 4.22E+3nMAssay Description:Inhibition of Flt1(unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of PDGFRA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of GRK5 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
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