BDBM50235830 CHEMBL2006765
SMILES CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
InChI Key InChIKey=UJBJWYNPUOLFIZ-UHFFFAOYSA-N
Data 65 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 65 hits for monomerid = 50235830
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 5.91E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 2.33E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 472nMAssay Description:Inhibition of AURKA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of BTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of PDGFRA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 136nMAssay Description:Inhibition of FAK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of TrkB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.73E+3nMAssay Description:Inhibition of CDK7 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 991nMAssay Description:Inhibition of TTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of Prkcn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 391nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.51E+3nMAssay Description:Inhibition of PKCtheta (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibition of TRKA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 433nMAssay Description:Inhibition of JNK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TAO2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 529nMAssay Description:Inhibition of TAOK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 266nMAssay Description:Inhibition of ALK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IKKE (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDeath-associated protein kinase 3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of ZIPK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Inhibition of ROCK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of CLK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of AURKB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of LTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 4.22E+3nMAssay Description:Inhibition of Flt1(unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ABL (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 892nMAssay Description:Inhibition of MAP4K4 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of CDK9 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.65E+3nMAssay Description:Inhibition of 125I-fibrinogen binding to alpha IIb beta-3 integrin as inhibition of activated plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 558nMAssay Description:Inhibition of 125I-fibrinogen binding to alpha IIb beta-3 integrin as inhibition of activated plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 496nMAssay Description:Inhibition of JAK3 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of human CAMK1D (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor-like protein(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 177nMAssay Description:Inhibition of MST1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of GRK5 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 606nMAssay Description:Inhibition of SGK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 9.06E+3nMAssay Description:Inhibition of CSF1R (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKG1A (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 886nMAssay Description:Inhibition of KDR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of PAK4 kinase domain (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 502nMAssay Description:Inhibition of INSR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair