BDBM50239952 CHEMBL4081997

SMILES NCCNS(=O)(=O)c1ccc(cc1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1

InChI Key InChIKey=YDCCHZDGDMSTQT-UHFFFAOYSA-N

Data  1 KI  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50239952   

TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataKi:  14nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  467nMAssay Description:Inhibition of recombinant human MMP12 expressed in baculovirus expression system using Mca-Pro-LeuGly-Leu-Dpa-Ala-Arg-NH2 as substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  730nMAssay Description:Inhibition of recombinant human MMP2 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagen alpha-1(II) chain(Homo sapiens)
Graz University Of Technology

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of Collagen-II-alpha 1 (unknown origin) incubated for 22 hrs by Coomassie blue staining based SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP9 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human MMP1 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human MMP13 using APMA and fTHP-15(FAM) as substrate preincubated for 30 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  730nMAssay Description:Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Graz University Of Technology

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  600nMAssay Description:Inhibition of MMP-8 (unknown origin) using fTHP-15(FAM) as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50: >1.00E+4nMAssay Description:Competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Graz University Of Technology

Curated by ChEMBL
LigandPNGBDBM50239952(CHEMBL4081997)
Affinity DataIC50:  600nMAssay Description:Inhibition of MMP8 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed