BDBM50241364 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid::4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid::4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid::CHEMBL1516::olmesartan

SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)O

InChI Key InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50241364   

TargetType-1 angiotensin II receptor(Bos taurus)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataIC50:  8.10nMAssay Description:In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexMore data for this Ligand-Target Pair
TargetCytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet glycoprotein VI(Homo sapiens (Human))
University Of Leeds

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bos taurus)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Bos taurus)
Sankyo

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataIC50:  7.70nMAssay Description:Displacement of radiolabeled angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortex membranesMore data for this Ligand-Target Pair