BDBM50241865 2,5-dideoxy-2,5-imino-D-altritol::2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine::CHEMBL469844

SMILES C([C@@H]1[C@H]([C@H]([C@H](N1)CO)O)O)O

InChI Key InChIKey=PFYHYHZGDNWFIF-UHFFFAOYSA-N

Data  2 KI  11 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50241865   

TargetProbable alpha-glucosidase Os06g0675700(Rice)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 1.71E+5nMpH: 5.0Assay Description:Inhibition of rice alpha-glucosidase assessed as D-glucose release at pH 5 after 10 to 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-glucosidase A(Caldocellum saccharolyticum)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 1.90E+4nMpH: 5.0Assay Description:Inhibition of Caldocellum saccharolyticum beta-glucosidase assessed as p-nitrophenol release at pH 5 by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAlpha-galactosidase(Arabian coffee)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 780nMpH: 6.5Assay Description:Inhibition of coffee bean alpha-galactosidase assessed as p-nitrophenol release at pH 6.5 by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLactase/phlorizin hydrolase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of rat intestinal lactase assessed as p-nitrophenol release by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 5.03E+5nMpH: 5.5Assay Description:Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at pH 5.5 by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 750nMpH: 7.0Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 1.00E+3nMpH: 4.6Assay Description:Inhibition of human recombinant lysosomal alpha GAL-A using 4-methylberiilyl alpha-D-galactopyranoside as substrate at pH 4.6 after 10 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 7 after 15 mins by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human alpha GAL-A using 4-methylumbelliferyl alpha-D-galactopyranoside as substrate at pH 4.6 after 15 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-galactosidase(Arabian coffee)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataIC50: 6.78E+5nMAssay Description:Inhibition of coffee bean alpha-galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Institut FüR Biochemie Der Technischen UniversitäT Graz

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50241865(2,5-dideoxy-2,5-imino-D-altritol | 2R,5R-dihydroxy...)
Affinity DataKi:  500nMAssay Description:Competitive inhibition of human lysosome alpha-galactosidase by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)