BDBM50242817 CHEMBL4087968
SMILES Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1
InChI Key InChIKey=WXHHICFWKXDFOW-BJMVGYQFSA-N
Data 40 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50242817
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in Baculovirus insect cell expression system using [3H]-metabolically labeled acetylated histone subs...More data for this Ligand-Target Pair
Affinity DataIC50: 432nMAssay Description:Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 864nMAssay Description:Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of HDAC in human HeLa cell extract using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human recombinant HDAC2 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluor-de-lys-green as substrate preincubated for 10 mins followed by substrate addition a...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant His-tagged HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant His-tagged HDAC2 (1 to 582 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS Green as subst...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate preincubated fo...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Hunan University Of Science And Technology
Curated by ChEMBL
Hunan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Hunan University Of Science And Technology
Curated by ChEMBL
Hunan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human His tagged HDAC1 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant human HDAC2 assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Inhibition of recombinant human HDAC3/NCOR1 assessed as decrease in deacetylation of FLUOR DE LYS SIRT1 substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of recombinant human His tagged HDAC6 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of recombinant human HDAC8 assessed as decrease in deacetylation of FLUOR DE LYS substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human HDAC1 using SIRT1 as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by flu...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human HDAC2 using FLUOR-DE-LYS-Green as substrate incubated for 10 mins followed by substrate addition and measured after 3...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of human recombinant HDAC1 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 10 mins followed by addition of substrate fluor De Lys green measured after 30 mins by fluores...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 complex preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measure...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human recombinant HDAC6 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human recombinant HDAC8 preincubated for 10 mins followed by substrate addition measured after 30 mins by fluorescent plate reader anal...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Hunan University Of Science And Technology
Curated by ChEMBL
Hunan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Beijing University Of Chemical Technology
Curated by ChEMBL
Beijing University Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 733nMAssay Description:Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Hunan University Of Science And Technology
Curated by ChEMBL
Hunan University Of Science And Technology
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute Of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of purified HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair