BDBM50246327 4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzenesulfonamide::4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide::CHEMBL509485

SMILES CNS(=O)(=O)c1ccc(Nc2ncc(c(N[C@@H]3CCC[C@H]3N(C)C)n2)C(F)(F)F)cc1

InChI Key InChIKey=CAUFYHKGKDJMQG-HZPDHXFCSA-N

Data  6 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246327   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  154nMAssay Description:Inhibition of GST-tagged pyk2 (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  88nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation by fluorescence polarization assayMore data for this Ligand-Target Pair