BDBM50254790 (S)-Norfluoxetine::CHEMBL465123::NORFLUOXETINE

SMILES c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F

InChI Key InChIKey=WIQRCHMSJFFONW-UHFFFAOYSA-N

Data  37 KI  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 50254790   

LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  1.47nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  3.15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  3.15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  13.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  30.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataIC50: 46nMAssay Description:Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  50nMAssay Description:Displacement of [125I]RTI55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  91.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  117nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  157nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  286nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  295nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  638nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat voltage-gated K channel 3.1 expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  810nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  1.43E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  2.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  2.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataIC50: 2.81E+3nMAssay Description:Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  3.05E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  3.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  3.95E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  4.54E+3nMAssay Description:Displacement of [125I]RTI55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  4.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  5.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi:  6.19E+3nMAssay Description:Displacement of [125I]RTI55 from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataEC50:  9.00E+3nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
LigandPNGBDBM50254790(NORFLUOXETINE | CHEMBL465123 | (S)-Norfluoxetine)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed