BDBM50257823 CHEMBL4089551

SMILES N#Cc1c[nH]c2nc(N)nc(-c3ccc(S(N)(=O)=O)cc3)c12

InChI Key InChIKey=MPTGZYHKBIOUAJ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257823   

TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257823BDBM50257823(CHEMBL4089551)
Affinity DataKi:  80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged IKKalpha (1 to 745 residues) expressed in baculovirus expression system using biotinylated IkBa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257823BDBM50257823(CHEMBL4089551)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant full length human IKKbeta expressed in baculovirus infected sf9 insect cells using biotinylated IkBalpha as substrate after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
University of Strathclyde

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50257823BDBM50257823(CHEMBL4089551)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of IKKalpha in human U2OS cells assessed as decrease in FCS induced p100 phosphorylation at ser866/870 residues preincubated for 1 hr foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed