BDBM50265287 CHEMBL521887::N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc3ccncc3c2)CC1

InChI Key InChIKey=IYCITBYBDPSBBJ-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50265287   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataKi:  830nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50:  700nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50:  800nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50:  70nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265287(CHEMBL521887 | N-(3-(isoquinolin-7-yl)-4-methylphe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed