BDBM50268463 CHEMBL502411::c[L-Phe-D-pro-L-Phe-D-trp]

SMILES O=C1N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@H]12

InChI Key InChIKey=GIZJWWQFOGQPRY-RRGQHJHPSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50268463   

TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]diprenorphine from human cloned kappa opioid receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  22nMAssay Description:Displacement of [3H]diprenorphine from rat KOP stably expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  30nMAssay Description:Displacement of [3H]diprenorphine from human cloned mu receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  31nMAssay Description:Displacement of [3H]diprenorphine from rat cloned KOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  259nMAssay Description:Displacement of [3H]DAMGO from rat cloned MOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  259nMAssay Description:Displacement of [3H]DAMGO from rat MOP stably expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]diprenorphine from human cloned delta receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  2.91E+3nMAssay Description:Displacement of [3H]DPDPE from mouse cloned DOR expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataKi:  4.19E+3nMAssay Description:Displacement of [3H]DPDPE from mouse DOP stably expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataIC50:  140nMAssay Description:Antagonist activity at human cloned kappa opioid receptor assessed as inhibition of 50 nM U50488H-stimulated GTPgammaS binding by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50268463(CHEMBL502411 | c[L-Phe-D-pro-L-Phe-D-trp])
Affinity DataIC50:  21nMAssay Description:Antagonist activity at human cloned mu opioid receptor assessed as inhibition of 100 nM loperamide-stimulated GTPgammaS binding by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed