BDBM50273541 CHEMBL516312::N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)nicotinamide

SMILES O=C(Nc1c[nH]c2ncc(cc12)-c1ccc(cc1)C#N)c1cccnc1

InChI Key InChIKey=JTSLALYXYSRPGW-UHFFFAOYSA-N

Data  4 KI  4 IC50  12 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50273541   

TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKi:  541nMAssay Description:Binding affinity to biotinylated AAK1 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assayMore data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKi:  1.75E+3nMAssay Description:Binding affinity to biotinylated GAK (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKi:  4.40E+3nMAssay Description:Binding affinity to biotinylated BMP2K (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKi:  1.19E+4nMAssay Description:Binding affinity to biotinylated STK16 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  160nMAssay Description:Binding affinity to human TNIKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  75nMAssay Description:Binding affinity to human MST2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  483nMAssay Description:Binding affinity to human NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  596nMAssay Description:Binding affinity to human AXLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  24nMAssay Description:Binding affinity to human MPSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase STK11(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  380nMAssay Description:Inhibition of LKB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataIC50:  1.17E+3nMAssay Description:Binding affinity to biotinylated AAK1 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assayMore data for this Ligand-Target Pair
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataIC50:  1.01E+4nMAssay Description:Binding affinity to biotinylated BMP2K (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataIC50:  2.00E+4nMAssay Description:Binding affinity to biotinylated STK16 (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  120nMAssay Description:Binding affinity to wild type DNA-tagged human AAK1 (G25 to L333 residues) expressed in bacterial expression system by quantitative PCR based KINOMEs...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataIC50:  3.25E+3nMAssay Description:Binding affinity to biotinylated GAK (unknown origin) incubated for 1.5 hrs by fluorescent tracer dependent TR-FRET based binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase STK11(Homo sapiens (Human))
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  380nMAssay Description:Binding affinity to human LKB1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  35nMAssay Description:Binding affinity to human PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  53nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  53nMAssay Description:Binding affinity to human AAK1More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Ku Leuven

Curated by ChEMBL
LigandPNGBDBM50273541(CHEMBL516312 | N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3...)
Affinity DataKd:  53nMAssay Description:Inhibition of AAK1More data for this Ligand-Target Pair