BDBM50278653 CHEMBL4163186::US10399948, Compound 20

SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)cc1=O

InChI Key InChIKey=VCOSHOBJZUQNSJ-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50278653   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataEC50:  316nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataEC50:  340nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  180nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  344nMAssay Description:HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  323nMAssay Description:Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Vanderbilt University

US Patent
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50: >3.00E+4nMAssay Description:Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278653(CHEMBL4163186 | US10399948, Compound 20)
Affinity DataIC50:  182nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed