BDBM50279080 (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylicAcid Methyl Ester::CHEMBL502835::methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

SMILES CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5

InChI Key InChIKey=XZXHXSATPCNXJR-UHFFFAOYSA-N

Data  39 IC50  2 Kd

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 50279080   

LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 3(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 35nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 2(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 41nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 58nMAssay Description:Inhibition of TRK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPlatelet-derived growth factor receptor alpha(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 85nMAssay Description:Inhibition of glutathione S-transferase fused PDGFbetaR (unknown origin) in 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 104nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataKd:  700nMAssay Description:Binding affinity to human MLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of FGFR in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetInsulin receptor(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human insulin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 6.03E+3nMAssay Description:Inhibition of FGFR in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of FGFR in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 7.25E+3nMAssay Description:Inhibition of FGFR in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 8.26E+3nMAssay Description:Inhibition of FGFR in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSerine/threonine-protein kinase PLK1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
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