BDBM50294451 CHEMBL565061::ethyl 7-(3-(3-(trifluoromethyl)benzamido)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate::pyrazolo[1,5-a]pyrimidine-3-carboxylate

SMILES CCOC(=O)c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=YCAVTOUTYRMOGQ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50294451   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Tpl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50294451(CHEMBL565061 | ethyl 7-(3-(3-(trifluoromethyl)benz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed