BDBM50296484 (S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}piperidin-1-ylmethanone::CHEMBL555563::VER-156084

SMILES Clc1ccc(cc1)[C@H](OC1CN(C1)C(=O)N1CCCCC1)c1cccnc1Cl

InChI Key InChIKey=QEKKZTBXSULKCC-IBGZPJMESA-N

Data  2 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50296484   

TargetCannabinoid receptor 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  7.19E+3nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  188nMAssay Description:Inhibition of human FAAH incubated 3 hrs prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human FAAH incubated 1 hr prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human FAAH incubated 3 hrs prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of rat FAAH incubated 1 hr prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  112nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  3.08E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  973nMAssay Description:Inhibition of human FAAH expressed in CHO cells using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  447nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  291nMAssay Description:Inhibition of human FAAH incubated 1 hr prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  531nMAssay Description:Inhibition of rat FAAH incubated 3 hrs prior to addition of arachidonylaminomethylcoumarin amideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of human recombinant N-His6-tagged MAGL expressed in Escherichia coli using 7-Hydroxycoumarinyl arachidonate as substrate by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed