BDBM50305258 2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole::CHEMBL605405

SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1

InChI Key InChIKey=XQDRWCFJBHLWPR-RAXLEYEMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50305258   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305258(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305258(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50305258(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Affinity DataIC50:  154nMAssay Description:Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed