BDBM50305450 CHEMBL592763::methyl (S)-4-(3-chlorophenyl)-4-((R)-1-((S)-1-cyclohexyl-3-(methylamino)propan-2-ylcarbamoyl)piperidin-3-yl)-4-hydroxybutylcarbamate

SMILES CNC[C@H](CC1CCCCC1)NC(=O)N1CCC[C@H](C1)[C@@](O)(CCCNC(=O)OC)c1cccc(Cl)c1

InChI Key InChIKey=WLSZRWKNFJAKEI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50305450   

TargetRenin(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305450(methyl (S)-4-(3-chlorophenyl)-4-((R)-1-((S)-1-cycl...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRenin(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305450(methyl (S)-4-(3-chlorophenyl)-4-((R)-1-((S)-1-cycl...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed