BDBM50311953 4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile::CHEMBL1080994

SMILES Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(S(=O)(=O)N3CCN(C)CC3)c2)ccc2[nH]ccc12

InChI Key InChIKey=GMQQMSKNSNVPOW-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50311953   

TargetProtein kinase C theta type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 18nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C eta type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PKCetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 140nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 220nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 290nMAssay Description:Inhibition of LYN AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 550nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of CDK2/cyclinAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetCasein kinase I isoform gamma-1(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CK1gamma1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RSk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Wyeth Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311953BDBM50311953(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKCzetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed