BDBM50313224 5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-indole-2-carboxylic acid::CHEMBL1076694

SMILES CC(C)Oc1ccc(cc1)-n1c(cc2cc(ccc12)-c1ccc(cc1)C(C)(C)C)C(O)=O

InChI Key InChIKey=GUMCVDVWBMLUSQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50313224   

TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  216nMAssay Description:Inhibition of recombinant human mPGES-1 expressed in human 293E cell microsomes using PGH2 as substrate assessed as PGE2 production after 2.5 mins by...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of purified mPGES-1 (1 to 152) (unknown origin) extracted from detergent-solubilized baculovirus-infected insect Sf9 cell membranes using ...More data for this Ligand-Target Pair