BDBM50313479 4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidine-2-carbonitrile::4-cycloheptyl-6-(3-piperidin-1-ylpropyl)pyrimidine-2-carbonitrile::CHEMBL1084403

SMILES N#Cc1nc(CCCN2CCCCC2)cc(n1)C1CCCCCC1

InChI Key InChIKey=UTNIKRVBYGTXDR-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50313479   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H] dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-MCA substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCathepsin B(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin B by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant cathepsin K by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetProcathepsin L(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50313479(4-cycloheptyl-6-(3-(piperidin-1-yl)propyl)pyrimidi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed