BDBM50317700 (4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluorophenoxy)pyrrolidin-2-yl)methanone::CHEMBL1095846

SMILES Fc1ccc(O[C@@H]2CN[C@H](C2)C(=O)N2CCCN(CC2)C2CCC2)cc1

InChI Key InChIKey=RKXDBMQRODRNSK-RBUKOAKNSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50317700   

TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of labeled dofetilide human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50317700((4-cyclobutyl-1,4-diazepan-1-yl)((2R,4S)-4-(4-fluo...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed