BDBM50329198 2-(ethyl((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)amino)-2-methylpropan-1-ol::2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol::CHEMBL1232515::CHEMBL1650533

SMILES CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO

InChI Key InChIKey=RHGZQGXELRMGES-UHFFFAOYSA-N

Data  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50329198   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 1nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of IRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PKCAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTestis-specific serine/threonine-protein kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CSNK1DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329198BDBM50329198(CHEMBL1650533 | 2-{ethyl[(5-{[6-methyl-3-(1H-pyraz...)
Affinity DataIC50: 180nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed