BDBM50330939 CHEMBL1278138::N-(2-Methylbenzyl)-6-(4-cyanophenyl)-pyrazine-2-carboxamide

SMILES Cc1ccccc1CNC(=O)c1cncc(n1)-c1ccc(cc1)C#N

InChI Key InChIKey=VYANEYBOMGSJQI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330939   

TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant NaV1.2 by electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)
Affinity DataIC50:  450nMAssay Description:Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50330939(CHEMBL1278138 | N-(2-Methylbenzyl)-6-(4-cyanopheny...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed