BDBM50335099 4-chlorobenzo[d]thiazol-2-amine::CHEMBL1413383::EN300-157593

SMILES Nc1nc2c(Cl)cccc2s1

InChI Key InChIKey=OEQQFQXMCPMEIH-UHFFFAOYSA-N

Data  4 KI  3 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50335099   

TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  7.90E+4nMAssay Description:Inhibition of Leishmania major PTR1 by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of N-terminal 6xHis-tagged PDE10A (unknown origin) expressed in BL21 (DE3) RIL cells using 3',5'-cGMP as substrate by microcalorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataKi:  2.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PDE10A2 catalytic domain expressed in Escherichia coli BL21(DE3) RIL cells using 3',5'-cGMP as substrate b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataIC50:  2.11E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetPteridine reductase 1(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of Leishmania major PTR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50335099(4-chlorobenzo[d]thiazol-2-amine | CHEMBL1413383 | ...)
Affinity DataIC50:  1.39E+6nMAssay Description:Inhibition of Leishmania major DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed