BDBM50341493 CHEMBL1765463::Ethyl 6-(5-(Phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]-pyridine-3-carboxylate

SMILES CCOC(=O)c1cnc2ccc(cn12)-c1cncc(NS(=O)(=O)c2ccccc2)c1

InChI Key InChIKey=SEKOTFCHZNXZMM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50341493   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PI3Kalpha after 180 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  59nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate by HTRF colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50: >5nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  104nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3Kgamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50341493(CHEMBL1765463 | Ethyl 6-(5-(Phenylsulfonamido)pyri...)
Affinity DataIC50:  87nMAssay Description:Inhibition of p110delta/p85alpha (unknown origin) using PIP2 as substrate by HTRF colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed