BDBM50341682 6,6'-(2,2'-(Pyridine-3,5-diyl)bis(ethane-2,1-diyl))bis(4methylpyridin-2-amine)::6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine)::CHEMBL1615288::NOS Inhibitor, 3j::US10759791, Compound 2a::US9951014, Name 2a
SMILES Cc1cc(N)nc(CCc2cncc(CCc3cc(C)cc(N)n3)c2)c1
InChI Key InChIKey=KZHFSPGMRFCRCE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50341682
Affinity DataKi: 25nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 1.45E+3nMAssay Description:Inhibition of mouse macrophage recombinant iNOS expressed in Escherichia coli by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 1.45E+3nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
Affinity DataKi: 1.45E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
Affinity DataKi: 1.45E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
Affinity DataKi: 2.68E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
Affinity DataKi: 2.68E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
Affinity DataKi: 2.68E+3nMAssay Description:Enzyme inhibition was evaluated by measuring NO production with the hemoglobin capture assay, which was performed with purified NOSs in 96-well plate...More data for this Ligand-Target Pair
Affinity DataKi: 2.68E+3nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli by UV-vis spectrometric analysisMore data for this Ligand-Target Pair
TargetNitric oxide synthase oxygenase(Bacillus subtilis (Firmicutes))
University Of California Irvine
University Of California Irvine
Affinity DataKd: 2.68E+3nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of nNOS expressed in human 293T cells assessed as nitrite formation after 8 hrs by Griess reactionMore data for this Ligand-Target Pair