BDBM50341795 (1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol-3-yl]-3-methylpiperazine-1-sulfonylamino}-2-methyl-3-phenylcyclopropanecarboxylic Acid::CHEMBL1766917

SMILES C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)N1CCN([C@H](C)C1)c1cc(on1)C(C)(F)F)C(O)=O

InChI Key InChIKey=WQDCDSSZTJOWCF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341795   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341795BDBM50341795((1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341795BDBM50341795((1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341795BDBM50341795((1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human recombinant MMP1 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341795BDBM50341795((1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant TACE after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed