BDBM50359190 CHEMBL1923127

SMILES COCCCc1cc(CCCN2CCOCC2)c(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@@]22OCc3cc(F)c(F)cc23)c1

InChI Key InChIKey=PIBCEYLKROLZIT-SJHOIFEDSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50359190   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50359190(CHEMBL1923127)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50359190(CHEMBL1923127)
Affinity DataIC50:  0.0700nMpH: 7.4Assay Description:Inhibition of recombinant human renin using 9 DNP-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-D,L-Amp as substrate after 3 hrs by Q-FRET assay in presence of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50359190(CHEMBL1923127)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant human renin in human plasma using QXL520-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-(5-FAM) as substrate preincubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50359190(CHEMBL1923127)
Affinity DataIC50:  2.60E+3nMAssay Description:Reversible inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed