BDBM50381677 CHEMBL1256748::U-69593
SMILES CN([C@H]1C[C@@]2(CCCO2)CC[C@@H]1N1CCCC1)C(=O)Cc1ccccc1
InChI Key InChIKey=PGJPPWQHDNODBR-JAXLGGSGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 50381677
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes.More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Displacement of radiolabeled U69593 from kappa1 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 0.880nMAssay Description:Displacement of [3H]U-69593 from kappa-opoid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 0.970nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 0.970nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane after 150 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor transfected in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity against opioid receptor kappa 1 from human cloned receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity against opioid receptor by displacing radioligand [3HlU69,593More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]U-69593 from guinea pig cerebellum KORMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Binding affinity determined against Opioid receptor kappa 1 from a native receptor in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]-U69593 from human kappa opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]U69,593 from human recombinant opioid kappa receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataKi: 4.80nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 5.70nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in Wistar rat brain membranes by liquid scintillation counting based competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 391nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes without cerebellum after 1 hr by liquid scintillation counting an...More data for this Ligand-Target Pair
Affinity DataKi: 548nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain membranes without cerebellum after 1 hr by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: 692nMAssay Description:Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity determined against Opioid receptor mu 1 from human cloned receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity determined against Opioid receptor delta 1 from human cloned receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from mouse whole brain MORMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from mouse whole brain DORMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Displacement of [3H]DAMGO from human recombinant Opioid receptor mu 1 on CHO cell membranes.More data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.36E+3nMAssay Description:Displacement of radiolabeled DPDPE-Cl from delta opioid receptor in Hartley guinea pig brainMore data for this Ligand-Target Pair
Affinity DataKi: 1.88E+3nMAssay Description:Binding affinity of compound was determined against Opioid receptor mu 1 from native receptor in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [3H]DAMGO from human recombinant opioid mu receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataKi: 2.37E+3nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Southern Research Institute
Curated by ChEMBL
Southern Research Institute
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: 7.25E+3nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Partial agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against Opioid receptor delta 1 from a native receptor in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]C1-DPDPE from human recombinant Opioid receptor delta 1 on CHO cell membranes.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]pCl-DPDPE from human delta opioid receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [3H]DADLE from human recombinant opioid delta receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting m...More data for this Ligand-Target Pair
Affinity DataKi: 1.25E+4nMAssay Description:Displacement of [3H]-DADLE from human delta opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibitory concentration was determined against Opioid receptor mu 1 using [3H]- DAMGO radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.97E+3nMAssay Description:Inhibitory concentration was determined against delta-opioid receptor using [3H]- DPDPE radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University Of Kentucky
Curated by ChEMBL
University Of Kentucky
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration against Opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as caclium mobilization after 1 hrs by fluorescence analy...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for inhibitory concentration against [3H]DPDPE binding at sites of delta-opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK-293 cells assessed as stimulation of [35S]-GTPgammaS binding after 30 mins by liquid...More data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Tested for inhibitory concentration against [3H]DAMGO binding at sites of mu-opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair