BDBM50384649 CHEMBL2037017
SMILES O=C(Nc1ccccc1N1CCNCC1)c1csc(n1)-c1ccc2OCCc2c1
InChI Key InChIKey=WRGSHXQBWJUKQD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50384649
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant His-tagged CHK1 using biotin-RSGLYRSPSMPENLNRPR as substrate after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataKd: <100nMAssay Description:Binding affinity to CHK1 by affinity-selection-mass spectrophotometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using biotin-RSGLYRSPSMPENLNRPR as substrate af...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Inhibition of CHK1 in human U2OS cells pretreated with hydroxyurea assessed as gamma-H2AX level after 2 hrs by immunofluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Inhibition of CHK1 in human U2OS cells assessed as phosphorylation of H2AX after 2 hrs by FITC/propidium iodide staining-based immunofluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of Cyclin E/CDK2 expressed in Sf9 cells using [33gamma]ATP after 1 hr by liquid scintillation counterMore data for this Ligand-Target Pair