BDBM50392791 CHEMBL2151321::US8486966, 1

SMILES CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1

InChI Key InChIKey=FZBVNCFBCNXULH-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50392791   

TargetTyrosine-protein kinase ABL1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TrkAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 3nMT: 2°CAssay Description:To measure JAK2 kinase activity, a commercially available purified enzyme may be used. The enzyme may be a C-terminal His6-tagged, recombinant, human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2013
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of SIKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PhKg2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 13.4nMAssay Description:Inhibition of SAPK2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 17.2nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 18.2nMAssay Description:Inhibition of cSrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 30.6nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 34.1nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 44.3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 64nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 68.3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 72.2nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 99.8nMAssay Description:Inhibition of WNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50392791BDBM50392791(CHEMBL2151321 | US8486966, 1)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed