BDBM50397635 CHEMBL2181721

SMILES Cc1noc(C)c1-c1ccc(C)c(c1)S(=O)(=O)NC1CCCC1

InChI Key InChIKey=YTFPNQZFSVSZGW-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50397635   

TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50397635(CHEMBL2181721)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:Inhibition of His6-tagged BRD4-BD12 expressed in Escherichia coli assessed as inhibition of binding to SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHGSGS...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50397635(CHEMBL2181721)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:Inhibition of His6-tagged BRD3 expressed in Escherichia coli assessed as inhibition of binding to SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHGSGSK-bio...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50397635(CHEMBL2181721)Copy SMILESCopy InChI

Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of biotin-labelled tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 br...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50397635(CHEMBL2181721)Copy SMILESCopy InChI

Affinity DataIC50:  503nMAssay Description:Inhibition of biotin-labelled tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 br...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50397635(CHEMBL2181721)Copy SMILESCopy InChI

Affinity DataIC50:  500nMAssay Description:Inhibition of His6-tagged BRD2 expressed in Escherichia coli assessed as inhibition of binding to SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHGSGSK-bio...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPurchaseCHEMBLMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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