BDBM50398308 CHEMBL2177331

SMILES COc1ccc2Oc3ccc(cc3C3(COC(N)=N3)c2c1)-c1cc(Cl)ccc1F

InChI Key InChIKey=WIRKEQRUHLXVOQ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50398308   

TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50398308(CHEMBL2177331)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50398308(CHEMBL2177331)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50398308(CHEMBL2177331)
Affinity DataIC50:  4.29E+3nMAssay Description:Inhibition of BACE1 in human HEK293 cells expressing APP Swedish mutant assessed as reduction in amyloid beta 40 production after overnight incubatio...More data for this Ligand-Target Pair