BDBM50400181 6‐bromo‐2,3‐dihydroxyanthracene‐9,10‐dione (Ligand 3)::CHEMBL2180321
SMILES Oc1cc2C(=O)c3ccc(Br)cc3C(=O)c2cc1O
InChI Key InChIKey=KYLYKQAFRDSXIV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50400181
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology
Curated by ChEMBL
Dalian University of Technology
Curated by ChEMBL
Affinity DataKi: 107nMAssay Description:Binding affinity to Mcl-1 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 132nMAssay Description:Binding affinity to Bcl-2 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [172-327](Human)
Dalian University of Technology
Dalian University of Technology
Affinity DataKd: 1.84E+3nMpH: 8.0 T: 25°CAssay Description:ITC experiments were carried out using iTC200 (Microcal LLC, Northampton, MA, USA) with each of the compounds 1-6 and Mcl-1 protein. The heat of rea...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 50400181
CellInduced myeloid leukemia cell differentiation protein Mcl-1 (aa 172-327)(Human)
Dalian University of Technology
Dalian University of Technology
ITC DataΔG°: -7.81kcal/mole −TΔS°: -2.46kcal/mole ΔH°: -5.35kcal/mole logk: 5.36E+5
pH: 8.0 T: 25.00°C
pH: 8.0 T: 25.00°C