BDBM50420956 CHEMBL2088091
SMILES Cc1cc(Nc2nc(NCc3cc(C)no3)ncc2Br)[nH]n1
InChI Key InChIKey=ITMSGQSFXHYWNM-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50420956
Affinity DataIC50: 158nMAssay Description:Inhibition of human FGFR1 phosphorylation expressed in COS1 cells after 1 hr by immunoblottingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human KDR phosphorylation expressed in VEGF-stimulated HUVEC treated 90 mins before VEGF stimulation measured after 5 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of human IGF1R phosphorylation expressed in IGF-1-stimulated knockout mouse R+ cells treated 30 mins before IGF-1 stimulation measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of human INSR phosphorylation over expressed in CHOT cells after 60 mins by immunoblottingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 631nMAssay Description:Inhibition of recombinant N terminal GST-tagged human KDR (805 to 1356) expressed in baculovirus infected Sf9 cells after 90 mins by caliper mobility...More data for this Ligand-Target Pair
Affinity DataIC50: 63.1nMAssay Description:Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...More data for this Ligand-Target Pair
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of recombinant N terminal His6-tagged human IGF1R (959 to end) expressed in baculovirus infected Sf21 cells after 80 mins by caliper mobil...More data for this Ligand-Target Pair