BDBM50427457 CHEMBL2326952::US10308662, Compound 25::US9505780, 25

SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCOCC1

InChI Key InChIKey=VRBZWFAUTHKRBB-UHFFFAOYSA-N

Data  19 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50427457   

TargetBromodomain-containing protein 4 [75-147](Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  277nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent
PDB3D Structure (crystal)
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  714nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.75E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.17E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  714nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetBromodomain-containing protein 4 [44-167](Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  277nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent
PDB3D Structure (crystal)
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TargetBromodomain-containing protein 4 [349-460](Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  628nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  714nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.75E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University of Modena and Reggio Emilia

Curated by ChEMBL

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  27nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.17E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  714nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetBromodomain-containing protein 4 [368-440](Human)
Signal Rx Pharmaceuticals

US Patent

LigandBDBM50427457(CHEMBL2326952 | US10308662, Compound 25 | US950578...)Copy SMILESCopy InChI

Affinity DataIC50:  628nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In DepthDetails US Patent

Copy BDB DOI
Copy reaction URL