BDBM50435526 CHEMBL2392500

SMILES N#CCC(=O)N1CCC[C@@H](n2nnc3cnc4[nH]ccc4c32)C1

InChI Key InChIKey=COGIAVJREKAVDL-UHFFFAOYSA-N

Data  3 KI  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50435526   

TargetTyrosine-protein kinase JAK1(Human)
Argenta Discovery

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50435526BDBM50435526(CHEMBL2392500)
Affinity DataKi:  1.5nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Argenta Discovery

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50435526BDBM50435526(CHEMBL2392500)
Affinity DataKi:  3.80nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Argenta Discovery

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50435526BDBM50435526(CHEMBL2392500)
Affinity DataKi:  24nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Argenta Discovery

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50435526BDBM50435526(CHEMBL2392500)
Affinity DataEC50:  114nMAssay Description:Inhibition of JAK1-mediated STAT3 phosphorylation in IL6-induced human TF1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)