BDBM50438235 CHEMBL2407986

SMILES CNC(=O)c1ccc(N2CCN(Cc3cc4NC(=O)C(C)Oc4c(OC)c3)CC2)c(C)c1

InChI Key InChIKey=RYIVIHMEZGCXHY-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50438235   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438235(CHEMBL2407986)
Affinity DataEC50:  1.00E+5nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438235(CHEMBL2407986)
Affinity DataEC50:  60nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438235(CHEMBL2407986)
Affinity DataIC50:  36nMAssay Description:Inhibition of human PARP1 catalytic activity after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed