BDBM50443231 CHEMBL3086884

SMILES Cc1cc(c(c(c1O)C)N)/N=N/c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI Key InChIKey=PJXWUXARDBIOKJ-UHFFFAOYSA-N

Data  7 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50443231   

TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  150nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  151nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  220nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  290nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  440nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain adjacent to zinc finger domain protein 2B(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  2.26E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataKi:  5.12E+3nMAssay Description:Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated IL-6 expression preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443231BDBM50443231(CHEMBL3086884)
Affinity DataIC50: 3.81E+4nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated nitric oxide production preincubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)