BDBM50443232 CHEMBL3086883

SMILES Cc1cc(c(cc1O)N)/N=N/c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI Key InChIKey=DZTGIRNXWSZBIM-UHFFFAOYSA-N

Data  14 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50443232   

TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  85nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi: <85nMAssay Description:Inhibition of human 6x-His-tagged BRD4 bromodomain 1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  100nMAssay Description:Inhibition of human 6x-His-tagged BRD3 bromodomain 1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  100nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD1 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  140nMAssay Description:Inhibition of human 6x-His-tagged BRD3 bromodomain 2 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Minnesota

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  140nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD3 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  340nMAssay Description:Inhibition of human 6x-His-tagged BRD4 bromodomain 2 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  340nMAssay Description:Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  2.18E+3nMAssay Description:Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  2.72E+3nMAssay Description:Displacement of fluorescein-labeled MS226 from recombinant human BRD7 after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  3.29E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human BAZ2b after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated nitric oxide production preincubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Mouse)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated IL-6 expression preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2B(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  5.52E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human PCAF after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNucleosome-remodeling factor subunit BPTF(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  6.06E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human BPTF after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
Icahn School of Medicine At Mount Sinai

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443232BDBM50443232(CHEMBL3086883)
Affinity DataKi:  7.97E+3nMAssay Description:Displacement of fluorescein-labeled MS239 from recombinant human SMARCA4 bromodomain after 1 hr by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed