BDBM50447560 CHEMBL3116399

SMILES O=C(Nc1cccnc1)c1ccc2n(CC3CCN(CC3)C(=O)c3ccccc3)cnc2c1

InChI Key InChIKey=UROBXDPDOFZURE-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50447560   

TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50447560(CHEMBL3116399)
Affinity DataIC50:  15nMAssay Description:Inhibition of full length C-terminal His6-tagged human NAMPT expressed in Escherichia coli Rosetta (DE3) cells using PRPP/NAM as substrate/cofactor p...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50447560(CHEMBL3116399)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as reduction in NAD level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair