BDBM50448744 CHEMBL3128014::US8835445, 25::US8835445, 34

SMILES Cc1cc2nc(-c3nccs3)n(-c3cc4nc(N)nc(N)c4cc3Cl)c2cc1C

InChI Key InChIKey=WSVACSSBUCFLCD-UHFFFAOYSA-N

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50448744   

TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

US Patent
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0110nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

US Patent
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

US Patent
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0160nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  7.60nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  8.80nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent