BDBM50453950 CHEMBL4203082::US11247989, Example 88

SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1

InChI Key InChIKey=RPDQYBNAJDAGIK-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50453950   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50:  1.16nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCREB-binding protein/Histone acetyltransferase p300(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50453950(CHEMBL4203082 | US11247989, Example 88)
Affinity DataEC50:  32nMAssay Description:Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expressionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB