BDBM50460550 CHEMBL4227325

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCSC)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI Key InChIKey=XBNFGEUHYGBDPE-CNDRSWSLSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460550   

TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataKd:  700nMAssay Description:Binding affinity to human PCSK9More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human PCSK9 preincubated for 30 mins followed by LDLR addition and measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human PCSK9 preincubated for 30 mins followed by EGF(A) addition and measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataIC50:  840nMAssay Description:Inhibition of human PCSK9 preincubated for 30 mins followed by ab20 addition and measured after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed