BDBM50460740 CHEMBL4228404

SMILES CN(C)c1ccc(cc1)-c1nnc2sc(\C=C\c3ccco3)nn12

InChI Key InChIKey=HYGNBMVDUWDIPJ-MDZDMXLPSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50460740   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50460740(CHEMBL4228404)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) using oligonucleosome as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50460740(CHEMBL4228404)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) using oligonucleosome as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50460740(CHEMBL4228404)
Affinity DataKd:  9.30E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed