BDBM50468051 CHEMBL4276959

SMILES Nc1cccc(c1)C(OCCN1CCCCC1)c1cc2nccc(C(O)=O)c2s1

InChI Key InChIKey=FTKYSFLMVOPKTH-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50468051   

TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  490nMAssay Description:Irreversible inhibition of recombinant KDM5B ARID/PhD1 domain deletion mutant (1 to 755 residues) (unknown origin) expressed in Escherichia coli usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  700nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 10 uM alpha-KG by succinate-glo demethyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  4.20E+3nMAssay Description:Irreversible inhibition of recombinant KDM4A (1 to 350 residues) (unknown origin) expressed in Escherichia coli using H3 (1 to 21 residues) K9me3 as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  5.50E+3nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using alpha-KG measured immediately by succina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50: >1.00E+5nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 1000 uM alpha-KG by succinate-glo demeth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  4.90E+3nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using alpha-KG by succinate-glo demethylase as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
The University Of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50468051(CHEMBL4276959)
Affinity DataIC50:  5.40E+3nMAssay Description:Irreversible inhibition of KDM5A ARID/PhD1 domain deletion mutant (1 to 739 residues) (unknown origin) using 100 uM alpha-KG by succinate-glo demethy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB