BDBM50502498 CHEMBL4518534
SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2C3=NCC(O)N3C=Nc12)[C@H](O)c1ccc(Cl)cc1
InChI Key InChIKey=LTPABOINPMWTKU-BHUSIORFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50502498
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics
Curated by ChEMBL
Prelude Therapeutics
Curated by ChEMBL
Affinity DataKi: 55nMAssay Description:Binding affinity to human recombinant PRMT5/MEP50 expressed in baculovirus infected High-five cells using histone 4 peptide as substrate assessed as ...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics
Curated by ChEMBL
Prelude Therapeutics
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of PRMT5 in human Granta-519 assessed as reduction in sDMA production incubated for 3 days by Western blotting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of PRMT1 (unknown origin) by hotspot assayMore data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Prelude Therapeutics
Curated by ChEMBL
Prelude Therapeutics
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PRMT5/MEP50 expressed in baculovirus infected High-five cells using histone 4 peptide as substrate in presence of [3H...More data for this Ligand-Target Pair